There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Marcel Verbeek |
| Institution: | Radboudumc |
| Department: | Neurology |
| Country: | |
| Proposed Analysis: | I aim to analyze the following research questions: - Are CSF amyloid beta40, amyloid beta 41, total and phosphorylated tau levels associated with the occurrence of cerebral amyloid angiopathy (CAA), as determined by the neuroimaging signs of CAA, i.e. cortivcal microbleeds (CMBs) and superficial siderosis (cSS)? - Does the presence of CAA (with CMBs and cSS as proxy to assess (degree of severity of) CAA lower the threshold of being diagnosed with Alzheimer's disease? Levels of t-tau and p-tau will serve as readout, i.e. the hyppothesis is that patients with a clincial diagnosis of Alzheimer's (or dementia) and with advanced CAA will have a lower load of neurofibrillary tangles (and thus CSF/ plasma t-tau and p-tau) compared to those indivuduals with Alzheimer's and no CAA. 3. To study the relation between CSF amyloid beta 40 with CSF / plasma t-tau and p-tau and clincial diagnosis of Alzheimer's / dementia (similar as research question 2, but than with the 'CAA biomarker of CSF amyloid beta40' instead of CMBs or cSS. |
| Additional Investigators | |
| Investigator's Name: | Bea Kuiperij |
| Proposed Analysis: | proposed analysis is as described by prof. MM Verbeek; dr. Kuiperij is part of Verbeek's group. |
