There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Sruthi Srinivasan |
| Institution: | University of Cambridge |
| Department: | Electrical Engineering |
| Country: | |
| Proposed Analysis: | We are looking into the feasibility of creating an atlas of averaged structural MRIs for multiple dementia stages. To do this, we require access to a large volume of MRIs with varying degrees of cortical atrophy, as we wish to quantify individual differences in regional atrophy between brains. Our lab focuses on using the optical imaging method near-infrared spectroscopy (NIRS) to reconstruct brain images of task-related activity. However, NIRS requires the use of anatomical priors to accurately localize brain activity to the appropriate region. As a result, each subject must have a structural MRI available in order to solve the NIRS reconstruction problem. For healthy individuals, we typically use the MNI152 atlas brain and avoid the need for subject-specific anatomical information. However, for dementia patients with atrophied brains, we cannot substitute this atlas brain, as it introduces many inaccuracies. As a result, we would like to investigate differences between individuals with varying levels of atrophy, and see if there is a possibility of averaging structural MRIs to create atlas images specifically tailored to different stages of dementia (MCI, AD, etc.). This would be of significant benefit to our upcoming clinical studies with NIRS, by reducing or eliminating the need for structural MRIs to be taken for each participant. |
| Additional Investigators | |
| Investigator's Name: | Emilia Butters |
| Proposed Analysis: | Same as described: Investigating differences in atrophy between participants to evaluate the feasibility of creating atlas images of different dementia stages |
| Investigator's Name: | Liam Collins-Jones |
| Proposed Analysis: | Same as described: Investigating differences in atrophy between participants to evaluate the feasibility of creating atlas images of different dementia stages |
| Investigator's Name: | Seb Morris |
| Proposed Analysis: | Same as described: Investigating differences in atrophy between participants to evaluate the feasibility of creating atlas images of different dementia stages |
| Investigator's Name: | Deepshikha Acharya |
| Proposed Analysis: | We are looking into the feasibility of creating an atlas of averaged structural MRIs for multiple dementia stages. To do this, we require access to a large volume of MRIs with varying degrees of cortical atrophy, as we wish to quantify individual differences in regional atrophy between brains. Our lab focuses on using the optical imaging method near-infrared spectroscopy (NIRS) to reconstruct brain images of task-related activity. However, NIRS requires the use of anatomical priors to accurately localize brain activity to the appropriate region. As a result, each subject must have a structural MRI available in order to solve the NIRS reconstruction problem. For healthy individuals, we typically use the MNI152 atlas brain and avoid the need for subject-specific anatomical information. However, for dementia patients with atrophied brains, we cannot substitute this atlas brain, as it introduces many inaccuracies. As a result, we would like to investigate differences between individuals with varying levels of atrophy, and see if there is a possibility of averaging structural MRIs to create atlas images specifically tailored to different stages of dementia (MCI, AD, etc.). This would be of significant benefit to our upcoming clinical studies with NIRS, by reducing or eliminating the need for structural MRIs to be taken for each participant. |
