There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Valentin Iaquinta |
| Institution: | University of Wisconsin Madison |
| Department: | Department of Medicine - Geriatrics |
| Country: | |
| Proposed Analysis: | Cerebral oxidative stress has been directly linked to pathways facilitating the amyloid-beta and tau related neuropathophysiology in AD. Smoking has been associated with significant cerebral oxidative stress. The amount of literature examining possible direct associations between smoking habits and these AD biomarkers is limited. I would like to utilize the ADNI database to examine if increased levels of current and past smoking are associated with elevated amyloid-beta and tau pathology. The specificity of the classification of smoking habits is dependent on the specificity of the smoking-related variables available in the database. At the most basic level smoking status can be split into never-smokers, past smokers, and current smokers; if more specific information is available, grouping may be based on continuous units like pack years. AD pathophysiology will be quantified by Amyloid-beta, csf tau, and ptau. Statistical analysis will control for age, sex, family history, APOE status, and clinical diagnosis. |
| Additional Investigators |
