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Principal Investigator  
Principal Investigator's Name: Stamatios Sotiropoulos
Institution: University of Nottingham
Department: Sir Peter Mansfield Imaging Centre
Country:
Proposed Analysis: We are planning to process the dMRI and fMRI data of ADNI3 through the HCP pipelines and obtain structural and functional connectivity maps for each subject. We will then use our recent approach for identifying connectivity divergences (https://www.science.org/doi/10.1126/sciadv.abq2022) to explore dysconnections and changes in brain organisation that are linked to pathology. Our project is a large scale effort to combine different datasets for identifying transdiagnostic effects of psychiatric and neurological conditions using quantitative connectivity mapping approaches that we have recently developed and were not possible before. This work is performed within a larger Research Programme (funded by the European Research Council: 101000969) and all investigators have research Good clinical practice and research integrity training. IRB approval is implicit within our University as it hosts the above programme grant and proposed work is within the remit of the objectives.
Additional Investigators  
Investigator's Name: Stephania Assimopoulos
Proposed Analysis: Post-doc to undertake the research
Investigator's Name: Shaun Warrington
Proposed Analysis: Post-doc to undertake the research
Investigator's Name: Martin Craig
Proposed Analysis: Research software developer and technician that will take care of centrally storing the data in our secure file servers and enable processing through our supercomputer in the Higher Performance Computing Centre of the University of Nottingham
Investigator's Name: Martin Craig
Proposed Analysis: Research software developer and technician that will take care of centrally storing the data in our secure file servers and enable processing through our supercomputer in the Higher Performance Computing Centre of the University of Nottingham