There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Debo Dong |
| Institution: | Southwest University (SWU) |
| Department: | Faculty of Psychology |
| Country: | |
| Proposed Analysis: | Hallucinations and delusions have been thought to be closely related with changes in triple brain networks, but little is known about the role of amyloid β (Aβ) burden (a key Alzheimer’s disease (AD) biomarker) in the relationship between these typical psychiatric symptoms and altered resting state functional connectivity (rsFC) in older adults in various stages of AD. This proposed analysis will examine the association between these psychiatric symptoms, Aβ burden, and rsFC using a large-scale dataset from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). We plan to include individuals (cognitively normal, mild cognitive impairment, and AD) who had completed assessments for psychiatric symptoms (Neuropsychiatric Inventory (NPI)/Neuropsychiatric Inventory Questionnaire (NPIQ)), PET Aβ data, and resting-state fMRI scans at baseline. Within and between rsFC of the Salience (SN), the Default Mode (DMN) and the Frontal Parietal network (FPN) will be associated with hallucinations and delusions. Then, we will evaluate the association between Aβ burden and rsFC. Lastly but importantly, the interaction between Aβ positivity and psychiatric symptoms on rsFC will be evaluated using linear regressions, controlling for age, diagnosis status, gender, sedatives and hypnotics use, and hypertension. We hypothesized that 1) severity of hallucinations and delusions will be strongly associated with altered rsFC and 2) Aβ burden will lead to an exacerbation of hallucinations and delusions. |
| Additional Investigators | |
| Investigator's Name: | Yulin Wang |
| Proposed Analysis: | Hallucinations and delusions have been thought to be closely related with changes in triple brain networks, but little is known about the role of amyloid β (Aβ) burden (a key Alzheimer’s disease (AD) biomarker) in the relationship between these typical psychiatric symptoms and altered resting state functional connectivity (rsFC) in older adults in various stages of AD. This proposed analysis will examine the association between these psychiatric symptoms, Aβ burden, and rsFC using a large-scale dataset from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). We plan to include individuals (cognitively normal, mild cognitive impairment, and AD) who had completed assessments for psychiatric symptoms (Neuropsychiatric Inventory (NPI)/Neuropsychiatric Inventory Questionnaire (NPIQ)), PET Aβ data, and resting-state fMRI scans at baseline. Within and between rsFC of the Salience (SN), the Default Mode (DMN) and the Frontal Parietal network (FPN) will be associated with hallucinations and delusions. Then, we will evaluate the association between Aβ burden and rsFC. Lastly but importantly, the interaction between Aβ positivity and psychiatric symptoms on rsFC will be evaluated using linear regressions, controlling for age, diagnosis status, gender, sedatives and hypnotics use, and hypertension. We hypothesized that 1) severity of hallucinations and delusions will be strongly associated with altered rsFC and 2) Aβ burden will lead to an exacerbation of hallucinations and delusions. |
