There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Na Sun |
| Institution: | Massachusetts Institute of Technology |
| Department: | Computer Science |
| Country: | |
| Proposed Analysis: | Alzheimer’s Disease (AD) is multifaceted and its heterogeneous phenotypic manifestation across cognition, pathology. Recent advancements in single-cell genomics and large-scale genetic studies provide excellent opportunities to map the molecular and genetic basis underlying cell-type-specific transcriptional changes in AD. In our recent study, we have prioritized the AD risk genes for each major brain cell type, including four vascular cell types and microglia. To further investigate the association between cell-type-specific dysregulated AD risk genes and multiple phenotypes (image, cognition and pathology), we request to access ADNI for expanding the datasets and data types and build machine learning and deep learning algorithms to better integrate the information from multimodality datasets. |
| Additional Investigators |
