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Principal Investigator  
Principal Investigator's Name: Kjera Schack
Institution: Banner
Department: Banner Alzheimer's Institue
Country:
Proposed Analysis: A number of different cardiovascular-related alleles for the CRP, MTHFR, and VEGF genes have been associated with AD risk and/or pathology. The aim of this study will be to examine the effects of these cardiovascular gene markers on imaging-based measures of amyloid and tau in cognitively unimpaired older adults. This study will also explore whether the interactions between APOE e4 carrier status and these alleles are associated with in vivo plaque and tangle load.
Additional Investigators  
Investigator's Name: Michael Malek Ahmadi
Proposed Analysis: A number of different cardiovascular-related alleles for the CRP, MTHFR, and VEGF genes have been associated with AD risk and/or pathology. The aim of this study will be to examine the effects of these cardiovascular gene markers on imaging-based measures of amyloid and tau in cognitively unimpaired older adults. This study will also explore whether the interactions between APOE e4 carrier status and these alleles are associated with in vivo plaque and tangle load.