There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Weichen Zhou |
| Institution: | University of Michigan Medical School |
| Department: | Department of Computational Medicine and Bioinfor |
| Country: | |
| Proposed Analysis: | The genetic etiology of Alzheimer’s disease (AD) is poorly understood. Somatic mutations in the brains with AD and other neurological disorders have been established as a potential mechanism for their pathophysiology. Somatic transposable elements (TEs) are prevalent in individual neurons in the cerebral cortex of the human brain, a region long associated with AD progression, and recent work has shown a connection between AD-associated Tau protein-mediated mechanisms with TE activity and somatic mutations. Unfortunately, few studies have investigated the role and genomic impact of TE in AD and related dementias in the survey of large-scale cohorts. In this proposal, we aim to employ a genome-wide scan to explore the functional impact of TE in AD and related dementias by leveraging the genomic and phenotypic data in large datasets. We will establish genetic patterns of somatic TEs that would reveal the potential pathogenesis of AD. We will build a predictive model based on TE expression profiles in different regions of AD brains and clinical information that could help routine research and clinical practice. This project will build on the foundation for future collaborations and funding proposals and would likely expand the molecular mechanisms underlying the pathogenesis of AD and related dementias. |
| Additional Investigators |
