There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Jonathan Rodean |
| Institution: | Stanford University |
| Department: | Division of Primary Care and Population Health |
| Country: | |
| Proposed Analysis: | Based on the infectious hypothesis of Alzheimer's disease, a number of studies have looked at the associated increase in the risk of dementia following a number of different types of infections. Herpes viruses are of particular interest, as they have been found at a higher rate in individuals with Alzheimer's disease than in cognitively normal individuals, although these results are controversial. These infectious studies almost exclusively use incident dementia as an outcome. However, this outcome is potentially limiting, as they are often reliant on administrative diagnoses and discount the potential gradient of cognitive functioning, especially in those individuals already with cognitive impairment. To our knowledge, only one study, using the Baltimore Longitudinal Study of Aging, has looked at standardized cognitive measures in relationship to a herpes zoster infection (Duggan 2022), which was only in 98% cognitively normal individuals. Our proposed study is to leverage ADNI’s adverse events data collection to identify cases of herpes zoster infection using a search of shingles, herpes, and zoster in the clinically reported free text. We will then use multivariable longitudinal models to compare changes from baseline neuropsychological assessments (focusing on ones present across all ADNI studies, like MMSE and NPI-Q) in those individuals without vs. with reported herpes zoster infection, stratified by baseline cognitive status to assess the relationship of a herpes zoster infection with cognitive decline. |
| Additional Investigators | |
| Investigator's Name: | Pascal Geldsetzer |
| Proposed Analysis: | Based on the infectious hypothesis of Alzheimer's disease, a number of studies have looked at the associated increase in the risk of dementia following a number of different types of infections. Herpes viruses are of particular interest, as they have been found at a higher rate in individuals with Alzheimer's disease than in cognitively normal individuals, although these results are controversial. These infectious studies almost exclusively use incident dementia as an outcome. However, this outcome is potentially limiting, as they are often reliant on administrative diagnoses and discount the potential gradient of cognitive functioning, especially in those individuals already with cognitive impairment. To our knowledge, only one study, using the Baltimore Longitudinal Study of Aging, has looked at standardized cognitive measures in relationship to a herpes zoster infection (Duggan 2022), which was only in 98% cognitively normal individuals. Our proposed study is to leverage ADNI’s adverse events data collection to identify cases of herpes zoster infection using a search of shingles, herpes, and zoster in the clinically reported free text. We will then use multivariable longitudinal models to compare changes from baseline neuropsychological assessments (focusing on ones present across all ADNI studies, like MMSE and NPI-Q) in those individuals without vs. with reported herpes zoster infection, stratified by baseline cognitive status to assess the relationship of a herpes zoster infection with cognitive decline. |
