ADNI | Active Investigations

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Active Investigations

There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.

Principal Investigator
Principal Investigator's Name:	Moriah Sokolowski
Institution:	Baycrest Hospital
Department:	Rotman Research Institute
Country:
Proposed Analysis:	Individuals with poor memory for details, but advantages in semantic conceptual processing are overrepresented in Science, Technology, Engineering and Mathematics (STEM) occupations and have paradoxically fewer cognitive complaints with aging, perhaps due to practised compensation (Fan et al., 2020 BMC; Zeman et al., 2020 Cortex). Thus, I hypothesize that individuals with high scores on a STEM occupation dimension, computed in our recent paper that quantifies occupations, will show reduced reliance on memory systems associated with visual re-experiencing and will be protected against clinical pathology during aging. I will examine how individual differences in measures of brain health (i.e., functional and structural connectivity and global efficiency) relate to occupation. I will process structural, resting-state, and diffusion MRI data using an automated neuroimaging pipeline developed at the RRI for TheVirtualBrain, an open-source platform for large-scale network modelling. I will quantify occupation using our novel occupation space (Yu, Sokolowski et al., 2023 BRM). I will use partial least squares analyses to identify spatial patterns of brain activity that represent the optimal association between brain health and occupation and examine whether individuals with high scores on the STEM occupation dimension exhibit fewer cognitive impairments with more pathology.
Additional Investigators
Investigator's Name:	Brian Levine
Proposed Analysis:	Individuals with poor memory for details, but advantages in semantic conceptual processing also appear to be protected against the negative effects of trauma. Therefore, Dr. Levine will also explore whether having a STEM occupation will be protective against experiencing negative effects of traumatic events in an aging sample.