There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
Principal Investigator | |
Principal Investigator's Name: | 佳汶 姜 |
Institution: | 潍坊医学院附属医院(临床医学院) |
Department: | 神经内科 |
Country: | |
Proposed Analysis: | 帕金森病(PD)是目前社会中仅次于阿尔茨海默氏症的第二大年龄相关神经退行性疾病,由衰老、环境因素和遗传因素共同引起。其病理表现主要为黑质多巴胺能神经元进行性退变和路易小体的形成,分析黑质致密部中神经元与帕金森的关系 |
Additional Investigators | |
Investigator's Name: | 赵 赵 |
Proposed Analysis: | PRKN蛋白能够维持线粒体功能,与线粒体自噬、线粒体融合和分裂、氧化应激控制和线粒体运输有关。PRKN和PINK1协同工作以维持线粒体疾病。PINK1通过氧化应激在线粒体外膜上积累,并在线粒体中募集和激活PRKN。同时,PRKN与泛素-蛋白酶体途径相连,以降解靶蛋白。因此,PRKN功能的丧失会影响线粒体降解和多巴胺能神经元的丧失,并与家族性帕金森病发作的病理机制密切相关 |