There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Pedro Vidor |
| Institution: | Universidade Federal do Rio Grande do Sul (Brazil) |
| Department: | Instituto de Ciências Básicas da Saúde |
| Country: | |
| Proposed Analysis: | Alzheimer’s disease (AD) and cerebral amyloid angiopathy (CAA) are both defined by damage of amyloid-β (Aβ) protein in the brain, the latter associated with its blood vessels (Greenberg, 2020). The accumulation of Aβ is also known for its correlation with the activity of microglial cells, which have been classified into multiple subtypes (Deczkowska, 2018; Stratoulias, 2019). Repair-associated microglia (RAM) is described as a source of vascular endothelial growth factor (VEGF; Mastorakos, 2021), a signal protein that has been previously correlated with better outcomes AD models (Herrán, 2013; Wang; 2011; Religa, 2013). Therefore, we aim to assess whether RAM had a significant overlap in the transcriptomic profiles of patients with AD and CAA trough their blood. |
| Additional Investigators |
