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Principal Investigator  
Principal Investigator's Name: Dilmini Wijesinghe
Institution: USC Stevens Neuroimaging and Informatics Institute
Department: USC Stevens Neuroimaging and Informatics Institute
Country:
Proposed Analysis: I am a new postdoctoral fellow in Dr. Jann's lab at INI working complexity measures in rs-fMRI data. This work is part of his NIA funded R01 The goal of this project is to further develop our Complexity Toolbox and a cloud-based pipeline for comprehensive complexity analysis of (large scale) fMRI data. We will systematically evaluate the complexity of fMRI as a novel imaging marker of AD populations, using the Alzheimer's Disease Neuroimaging Initiative (ADNI-3). Finally, we will use advanced machine learning techniques to evaluate complexity of rs-fMRI as a predictor for transversion from healthy to MCI and to AD. We will generate a disease staging model based on multimodal AD biomarkers including PET, CSF and rs-fMRI measures
Additional Investigators  
Investigator's Name: Kay Jann
Proposed Analysis: The goal of this project is to further develop our Complexity Toolbox and a cloud-based pipeline for comprehensive complexity analysis of (large scale) fMRI data. We will systematically evaluate the complexity of fMRI as a novel imaging marker of AD in LOAD populations, using rs-fMRI and PET data from Alzheimer's Disease Neuroimaging Initiative (ADNI-3). Finally, we will use advanced machine learning techniques to evaluate complexity of rs-fMRI as a predictor for transversion from healthy to MCI and to AD. We will generate a disease staging model based on multimodal AD biomarkers including PET, CSF and rs-fMRI measures