There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Arianna MOss |
| Institution: | University of California, Irvine |
| Department: | Neurobiology and Behavior |
| Country: | |
| Proposed Analysis: | Depression is a modifiable risk factor of Alzheimer’s disease (AD) and constitutes a potential target for new therapeutic interventions to prevent the onset or progression of cognitive impairment. Recently, cerebrospinal fluid (CSF) amyloid and tau biomarkers for AD have permitted a more robust understanding and earlier detection of AD. We aim to combine the diagnostic power of CSF biomarkers of AD with imaging to understand the foundational interactions between dementia and depression. This will lay the groundwork for research investigating how antidepressants modulate further cognitive decline and research into the inflammatory mechanisms linking depression and dementia. |
| Additional Investigators |
