There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Rachel Mis |
| Institution: | Temple University |
| Department: | Psychology |
| Country: | |
| Proposed Analysis: | Cognitive complaints are common in survivors of breast. Breast cancer survivors with cognitive complaints frequently do not meet criteria for established neurocognitive impairment diagnoses but nonetheless report significant effects on their daily functioning and quality of life. The current model of cognitive changes following breast cancer suggests that cancer and its treatment may accelerate aging processes. Despite this popular model, little is known about how cognitive changes in older women with breast cancer compare to other aging cohorts. For instance, it is now recognized that individuals with pre-clinical Alzheimer’s disease may begin to show subtle changes in cognitive functioning prior to receiving a diagnosis of mild cognitive impairment. It is unknown whether cancer related cognitive impairment may represent a similar risk for future cognitive decline that could be observable early in the process. In our study, we propose to compare older women with a history of breast cancer to groups of individuals at risk for Alzheimer’s disease to further characterize the nature of cancer related cognitive impairment. We propose to compare our sample of older women breast cancer survivors to ADNI participants who go on to develop a confirmed diagnosis of Alzheimer’s disease (or other type of dementia) on measures of episodic memory, language, executive functions, and visuospatial skills. This study will be among the first of its kind to leverage the power of two large cohorts in characterizing cognitive function among vulnerable groups of older women. Specific Aim: Compare cognitive performance among older women with breast cancer, non-cancer & non-dementia controls, women with MCI, and women with Alzheimer’s disease. The first basic analysis will be a cross-sectional comparison of cognitive performance among 4 groups: (1) Breast cancer survivors (TLC cohort); (2) Patients diagnosed with Alzheimer’s disease (ADNI cohort); (3) Patients diagnosed with MCI (ADNI cohort); and (4) Heathy controls (ADNI cohort). |
| Additional Investigators | |
| Investigator's Name: | Kathleen Van Dyk |
| Proposed Analysis: | Cognitive complaints are common in survivors of breast. Breast cancer survivors with cognitive complaints frequently do not meet criteria for established neurocognitive impairment diagnoses but nonetheless report significant effects on their daily functioning and quality of life. The current model of cognitive changes following breast cancer suggests that cancer and its treatment may accelerate aging processes. Despite this popular model, little is known about how cognitive changes in older women with breast cancer compare to other aging cohorts. For instance, it is now recognized that individuals with pre-clinical Alzheimer’s disease may begin to show subtle changes in cognitive functioning prior to receiving a diagnosis of mild cognitive impairment. It is unknown whether cancer related cognitive impairment may represent a similar risk for future cognitive decline that could be observable early in the process. In our study, we propose to compare older women with a history of breast cancer to groups of individuals at risk for Alzheimer’s disease to further characterize a nature of cancer related cognitive impairment. We propose to compare our sample of older women breast cancer survivors to ADNI participants who go on to develop a confirmed diagnosis of Alzheimer’s disease (or other type of dementia) on measures of episodic memory, language, executive functions, and visuospatial skills. This study will be among the first of its kind to leverage the power of two large cohorts in characterizing cognitive function among vulnerable groups of older women. Specific Aim: Compare cognitive performance among older women with breast cancer, non-cancer & non-dementia controls, women with MCI, and women with Alzheimer’s disease. Proposed Analyses: The first basic analysis will be a cross-sectional comparison of cognitive performance among 4 groups: (1) Breast cancer survivors (TLC cohort); (2) Patients diagnosed with Alzheimer’s disease (ADNI cohort); (3) Patients diagnosed with MCI (ADNI cohort); (4) Heathy controls (ADNI cohort). |
