There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Kedar Madi |
| Institution: | Atrium Health Wake Forest Baptist, Wake Forest School of Medicine |
| Department: | Radiology |
| Country: | |
| Proposed Analysis: | Hippocampal Morphometry: Analyze surface-based shape changes of the human hippocampus in those with Alzheimer's Disease (AD). Hippocampal volumes will be segmented from T1-weighted MR images. Volumes will then be processed through SlicerSALT (a shape analysis-focused fork of 3D Slicer) using spherical harmonics (SPHARM-PDM) to generate surface meshes of every hippocampus, complete with alignment and registration. Vector-based distances between every correspondent vertex will be calculated from each subject's hippocampus at multiple timepoints, then inputted into a statistical linear model paradigm alongside variables such as amyloid/tau deposition levels (SUVR values, etc.) and cognitive test scores. P-value "heat maps" of the hippocampal surface will show regions of shape change that are significantly correlated with AD diagnosis/status, cognitive test scores (multiple domains), amyloid/tau deposition levels, etc. Results will be used to inform and guide clinical approaches to diagnosis and identification of AD pathology at various stages of progression. |
| Additional Investigators |
