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Principal Investigator  
Principal Investigator's Name: Rui Yin
Institution: Nanjing First Hospital, Nanjing Medical University
Department: Sports Medicine and Joint Surgery
Country:
Proposed Analysis: We have proposed a generative model based on stable diffusion for the generation of progressive trajectories of degenerative diseases. Our model has shown good results in osteoarthritis. We hope to apply the data to further validate our model performance in neurodegenerative diseases such as Alzheimer's.
Additional Investigators  
Investigator's Name: Hao Chen
Proposed Analysis: 1. Fine-tuning our model on the patient's baseline T1-weighted MRI 2. Generate patients' follow-up brain MRI 3. Evaluate our model performance based on the structural similarity index (SSIM) between the ground truth (i.e., real image) and its corresponding generated image