There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Mei Chenghan |
| Institution: | Sichuan university |
| Department: | West China School of Medicine |
| Country: | |
| Proposed Analysis: | We aim to investigate the relationship between periodontitis and cerebrovascular pathology in the development of Alzheimer's disease. Firstly, patients with a history of periodontitis diagnosis will be screened for the presence of cerebrovascular lesions before confirming the diagnosis of Alzheimer's disease. We will analyze the localization of cerebrovascular lesion sites in relation to the accumulation of Abeta plaques and Tau neurofibrillary tangles in the brain, which are hallmark pathological features of Alzheimer's disease. Furthermore, it has been reported in the literature that individuals carrying the APOE4 gene variant have higher blood-brain barrier permeability compared to those with the APOE3 variant. Therefore, we also plan to investigate the association between periodontitis and the presence of APOE4 in individuals with Alzheimer's disease. This analysis will help us understand the potential role of APOE4 and blood-brain barrier dysfunction in the link between periodontitis and Alzheimer's disease. By examining these aspects, we hope to gain insights into the intricate mechanisms underlying the development and progression of Alzheimer's disease in individuals with periodontitis and its potential interaction with cerebrovascular pathology and genetic factors like APOE4. |
| Additional Investigators |
