There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Gonzalo Forno |
| Institution: | Universidad de los Andes |
| Department: | Psychology |
| Country: | |
| Proposed Analysis: | Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a relatively new terminology for subjects with age-related TDP-43 pathological changes associated with cognitive impairment. LATE neuropathological changes (LATE-NC) are most often located in a limbic distribution, starting in the amygdala and progressing to the hippocampus and middle-frontal gyrus at the end stage. TDP-43 inclusions are also found in up to 57% of Alzheimer’s disease cases associated with a lower threshold for developing dementia and accelerated cognitive decline. Despite this, it is not clear how subcortical regions for AD may be affected due to LATE-NC. Using the ADNI2 cohort data set, this project aims to study brain structural changes through a cross-sectional and longitudinal analysis. Specifically, we will analyze how cortical and subcortical areas are affected by LATE-NC, AD without co-pathology, and AD with TDP-43 co-pathology. We will further relate those changes to cognitive impairment. We intend to compare patients from early MCI to AD dementia and healthy controls, using a multifeatured approach combining neuropathology, MRI, and cognitive data. |
| Additional Investigators | |
| Investigator's Name: | Michael Hornberger |
| Proposed Analysis: | Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a relatively new terminology for subjects with age-related TDP-43 pathological changes associated with cognitive impairment. LATE neuropathological changes (LATE-NC) are most often located in a limbic distribution, starting in the amygdala and progressing to the hippocampus and middle-frontal gyrus at the end stage. TDP-43 inclusions are also found in up to 57% of Alzheimer’s disease cases associated with a lower threshold for developing dementia and accelerated cognitive decline. Despite this, it is not clear how subcortical regions for AD may be affected due to LATE-NC. Using the ADNI2 cohort data set, this project aims to study brain structural changes through a cross-sectional and longitudinal analysis. Specifically, we will analyze how cortical and subcortical areas are affected by LATE-NC, AD without co-pathology, and AD with TDP-43 co-pathology. We will further relate those changes to cognitive impairment. We intend to compare patients from early MCI to AD dementia and healthy controls, using a multifeatured approach combining neuropathology, MRI, and cognitive data. |
| Investigator's Name: | Rachel Tan |
| Proposed Analysis: | Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a relatively new terminology for subjects with age-related TDP-43 pathological changes associated with cognitive impairment. LATE neuropathological changes (LATE-NC) are most often located in a limbic distribution, starting in the amygdala and progressing to the hippocampus and middle-frontal gyrus at the end stage. TDP-43 inclusions are also found in up to 57% of Alzheimer’s disease cases associated with a lower threshold for developing dementia and accelerated cognitive decline. Despite this, it is not clear how subcortical regions for AD may be affected due to LATE-NC. Using the ADNI2 cohort data set, this project aims to study brain structural changes through a cross-sectional and longitudinal analysis. Specifically, we will analyze how cortical and subcortical areas are affected by LATE-NC, AD without co-pathology, and AD with TDP-43 co-pathology. We will further relate those changes to cognitive impairment. We intend to compare patients from early MCI to AD dementia and healthy controls, using a multifeatured approach combining neuropathology, MRI, and cognitive data. |
