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Principal Investigator  
Principal Investigator's Name: Chaofan Geng
Institution: Capital Medical University,
Department: Department of Neurology, Xuanwu Hospital,
Country:
Proposed Analysis: Neuroimaging Initiative (ADNI) database. ADNI is a longitudinal multicenter study that provides clinical data, imaging, genetic, and biochemical biomarkers information for the early detection and tracking of AD。AD-RAI outperformed plasma NfL in predicting syndromal conversion among preclinical and prodromal AD subjects. Combination of clinical features, plasma p-tau181, APOE ε4 genotype, and AD-RAI provides the best model in identifying early AD subjects with high risk of conversion to next syndromal stage. The validity of this model needs to be confirmed in a separate larger cohort.
Additional Investigators