There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Yen Ying Lim |
| Institution: | The University of Melbourne |
| Department: | Florey Institute of Neuroscience and Mental Health |
| Country: | |
| Proposed Analysis: | Aim: To determine the effects of APOE and BDNF Val66Met on amyloid-related cognitive decline Previously, using data from the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study, we reported that BDNF Val66Met moderates amyloid-related cognitive decline and hippocampal atrophy in healthy older adults (Lim et al., 2013, Neurobiology of Aging) and in adults with MCI (Lim et al., 2014, PLOSONE). In particular, amyloid positive individuals who were Val/Val homozygotes were able to tolerate the toxic effects of amyloid on cognitive function and hippocampal volume better than amyloid positive individuals who were Met homozygotes. However, given the small sample sizes, these studies were unable to determine the effect of APOE genotype on the relationship between BDNF, amyloid and cognitive function. Given the similarities in cohort characteristics and neuropsychological tests employed in the AIBL study and in the Alzheimer's Disease Neuroimaging Initiative (ADNI), we are seeking access to ADNI data so as to combine the two cohorts and to determine whether there are any interactions between APOE, BDNF, amyloid and cognitive function in individuals at high risk for developing Alzheimer's disease. |
| Additional Investigators |
