Principal Investigator
John C. Morris, M.D.
Washington University
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The Neuropathology Core FRCPath, directed by John C. Morris, M.D. and co-directed by Richard Perrin, MD, Ph.D., follows the following guiding principles:

• Neuropathological examination is essential to validate the clinical diagnoses in the ADNI study groups;
• Variability in methods and interpretation of lesions among individual neuropathologists requires a central laboratory, using state-of-the-art methods and up-to-date criteria to establish uniform and standard neuropathological diagnoses;
• Clinical-neuroimaging-neuropathological correlations in any ADNI participant who comes to autopsy will be of exceptional value; and
• The archiving of fixed and frozen brain tissue will facilitate biomarker studies of the earliest stages of AD.

Dr. John Morris is a member of the Alzheimer’s Association’s Medical & Scientific Advisory Committee. He chairs the Clinical Task Force for the NIA’s Alzheimer Disease Centers program. He is author or co-author of over 300 peer-reviewed journal articles and 50 chapters and reviews. He edited the first and second editions of the Handbook of Dementing Illnesses.

Resources

• ADNI Biospecimens Data Overview
• ADNI NPC Protocol
• Request ADNI Samples

Further Neuropathology Core documents can be found on the Study Documents page.