Biospecimen Data

One of the goals of ADNI is the collection of biospecimens, including blood, urine, and cerebrospinal fluid (CSF) from participants. Interested investigators, whether associated with an ADNI site or not, are encouraged to apply for use of this limited resource. However, use of ADNI samples for technology development or comparisons among different technologies is not recommended for well-established analysis  unless there is preliminary data showing clearly superior performance.

Additionally, several analyses results performed by the ADNI Biomarker Core will be available in the Data Archive as follows:

  • Homocysteine
  • Species of isoprostanes
  • CSF tau, sAPPβ levels, BACE levels, and enzyme activity
  • Plasma Aβ 40 and Aβ 42
  • Other promising CSF and plasma based on ongoing multiplex immunoassay studies and mass spectrometry MRM studies

For information about access to biospecimen samples, or to apply, visit the ADNI-info website. Go to the biomarker analysis webpage to read the methodology documents provided by the respective labs.

ADNI 1 Biospecimen Collection

All Participants: Urine all visits
Plasma from Blood all visits
Serum from Blood all visits
CSF baseline and month 12
Blood for NCRAD baseline
Blood for APOE screening
Cell Immortalization baseline

 

ADNI GO Biospecimen Collection

EMCI Participants: CSF screening
Plasma from Blood all visits
Serum from Blood all visits
APOE/GWAS baseline
Cell Immortalization baseline
ADNI 1 Continuing Participants: RNA
GWAS

 

ADNI 2 Biospecimen Collection

New Controls, EMCI and LMCI Participants: CSF baseline and every two years
Buffy Coat all visits
Plasma from Blood all visits
Serum from Blood all visits
RNA baseline, then yearly
APOE/GWAS baseline
Cell Immortalization baseline
New AD Participants: CSF baseline and Month 24
Buffy Coat all visits
Plasma from Blood all visits
Serum from Blood all visits
RNA baseline, Months 12 and 24
APOE/GWAS baseline
Cell Immortalization baseline
ADNI 1/GO Continuing Participants: CSF baseline, then every two years
Buffy Coat baseline, then yearly
Plasma from Blood baseline, then yearly
Serum from Blood baseline, then yearly
RNA baseline, then yearly
GWAS baseline if not obtained in ADNI GO

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