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Biospecimen Data

One of the goals of ADNI is the collection of biospecimens, including blood, urine, and cerebrospinal fluid (CSF) from participants. Interested investigators, whether associated with an ADNI site or not, are encouraged to apply for use of this limited resource. However, use of ADNI samples for technology development or comparisons among different technologies is not recommended for well-established analysis unless there is preliminary data showing clearly superior performance.

Additionally, several analyses results performed by the ADNI Biomarker Core will be available in the Data Archive as follows:

  • Homocysteine
  • Species of isoprostanes
  • CSF tau, sAPPβ levels, BACE levels, and enzyme activity
  • Plasma Aβ 40 and Aβ 42
  • Other promising CSF and plasma based on ongoing multiplex immunoassay studies and mass spectrometry MRM studies

For information about access to biospecimen samples, or to apply, visit the Access Samples page. View methodology documents provided by the respective labs in the Biomarker Analysis section.

 

ADNI 1 Biospecimen Collection

 

All Participants: Urine all visits
Plasma from Blood all visits
Serum from Blood all visits
CSF baseline and month 12
Blood for NCRAD baseline
Blood for APOE screening
Cell Immortalization baseline

 

CSF1: CSF was not collected from everyone in ADNI-1, just those that volunteered and consented to have a lumbar puncture. Urine and blood were collected on everyone

ADNI GO Biospecimen Collection

 

EMCI Participants: CSF screening
Plasma from Blood all visits
Serum from Blood all visits
APOE/GWAS baseline
Cell Immortalization baseline
ADNI 1 Continuing Participants: RNA
GWAS

 

ADNI 2 Biospecimen Collection

 

New Controls, EMCI and LMCI Participants: CSF baseline and every two years
Buffy Coat all visits
Plasma from Blood all visits
Serum from Blood all visits
RNA baseline, then yearly
APOE/GWAS baseline
Cell Immortalization baseline
New AD Participants: CSF baseline and Month 24
Buffy Coat all visits
Plasma from Blood all visits
Serum from Blood all visits
RNA baseline, Months 12 and 24
APOE/GWAS baseline
Cell Immortalization baseline
ADNI 1/GO Continuing Participants: CSF 1st ADNI 2 visit, then every two years
Buffy Coat 1st ADNI 2 visit, then yearly
Plasma from Blood 1st ADNI 2 visit, then yearly
Serum from Blood 1st ADNI 2 visit, then yearly
RNA 1st ADNI 2 visit, then yearly
GWAS 1st ADNI 2 visit if not obtained in ADNI GO